MOTS-c Half-Life Calculator
MOTS-c is a mitochondrial-derived peptide — encoded in mitochondrial DNA rather than the nucleus, which makes it genuinely unusual. Its half-life is short, and this calculator charts what that means across an every-other-day interval.
Half-life 1.5 hours · peaks at 30 min
Every 2 days.
Half-life
Left at next dose
MOTS-c · every other day · levels plateau after ~7.5 hours
Steady-state peak
1 mg
Steady-state trough
0 mg
Accumulation
None
At every other day, each dose has essentially cleared before the next one — levels don't accumulate, they repeat the same rise and fall. Clearance after a dose takes about 7.5 hours.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published MOTS-c half-life of about 1.5 hours. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
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What a 1.5 hours half-life means in practice
A half-life of 1.5 hours against every other day dosing means each dose has essentially cleared before the next arrives. That shapes the curve in three ways:
1. One half-life
Half the dose is gone after 1.5 hours. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing every other day means the next dose lands 2 days later, with about 0% of the previous one still present.
3. Accumulation and plateau
Almost nothing carries over, so levels don't accumulate — each dose repeats the same rise and fall, clearing in about 7.5 hours.
Worked example
MOTS-c has a half-life of 1.5 hours. Dosing every other day, the next dose arrives 2 days later with about 0% of the previous one still on board. That's little enough that levels don't build up: each dose rises and falls on its own, clearing in about 7.5 hours.
Encoded in mitochondrial DNA
Almost every peptide in the body is encoded in nuclear DNA. MOTS-c belongs to a small class encoded in the mitochondrial genome, discovered relatively recently, and the finding that mitochondria produce signalling peptides at all was itself notable — it implies a communication channel from mitochondria to the rest of the cell that was not previously mapped.
The research examines metabolic regulation and exercise-related pathways, largely in cell and animal models. Its half-life is short enough that on a multi-day interval each administration clears completely before the next, so nothing accumulates.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.