Survodutide Half-Life Calculator
Survodutide is an investigational dual agonist at the GLP-1 and glucagon receptors, in clinical development. Its half-life supports weekly dosing with substantial carry-over between doses — this calculator charts the accumulation and the clearance.
Half-life 5.1 days · peaks at 19 hours
Every 7 days.
Half-life
Left at next dose
Survodutide · once weekly · levels plateau after ~26 days
Steady-state peak
1.62 mg
Steady-state trough
0.69 mg
Accumulation
1.6×
At once weekly, each dose lands before the previous one has cleared, so levels stack to about 1.6× a single dose before plateauing — roughly 26 days in. After the last dose it takes about 26 days to clear.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published Survodutide half-life of about 5.1 days. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
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What a 5.1 days half-life means in practice
A half-life of 5.1 days against once a week dosing means each dose lands before the previous one has gone. That changes the curve in three ways:
1. One half-life
Half the dose is gone after 5.1 days. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once a week means the next dose lands 7 days later, with about 39% of the previous one still present.
3. Accumulation and plateau
Those leftovers stack until intake matches elimination — about 1.6× a single dose, reached after roughly 26 days (five half-lives).
Worked example
Survodutide has a half-life of 5.1 days. Dosing once a week, the next dose arrives 7 days later with about 39% of the previous one still on board. Levels therefore stack to roughly 1.6× a single dose before plateauing, which takes about 26 days — and after a final dose it takes about the same again to clear.
Two receptors, one of them counterintuitive
Survodutide activates the GLP-1 receptor and the glucagon receptor. Adding glucagon activity looks contradictory at first, because glucagon's classical role is raising blood glucose. The rationale rests on glucagon's separate effects on energy expenditure and hepatic fat, with GLP-1 co-agonism intended to offset the glycaemic direction.
Its reported time-to-peak is notably short for a weekly compound — under a day — while the half-life runs to several days. That combination produces a curve that rises quickly then declines slowly, rather than the gentler rise of compounds with slower absorption. Across repeated weekly dosing the peaks stack on a rising baseline until the plateau is reached.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.