Mazdutide Half-Life Calculator
Mazdutide is a dual GLP-1 and glucagon receptor agonist based on the oxyntomodulin structure, developed primarily through trials in China. Its half-life is at the long end of the weekly class, producing pronounced accumulation — this calculator charts it.
Half-life 8 days · peaks at 3 days
Every 7 days.
Half-life
Left at next dose
Mazdutide · once weekly · levels plateau after ~40 days
Steady-state peak
2.19 mg
Steady-state trough
1.51 mg
Accumulation
2.2×
At once weekly, each dose lands before the previous one has cleared, so levels stack to about 2.2× a single dose before plateauing — roughly 40 days in. After the last dose it takes about 40 days to clear.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published Mazdutide half-life of about 8 days. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
Never do this math twice.
The Pep AI app remembers your vials and doses, shows an interactive syringe you draw to, counts down the doses left in each vial, and reminds you when it's time. Free on iOS and Android.
What a 8 days half-life means in practice
A half-life of 8 days against once a week dosing means each dose lands before the previous one has gone. That changes the curve in three ways:
1. One half-life
Half the dose is gone after 8 days. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once a week means the next dose lands 7 days later, with about 55% of the previous one still present.
3. Accumulation and plateau
Those leftovers stack until intake matches elimination — about 2.2× a single dose, reached after roughly 40 days (five half-lives).
Worked example
Mazdutide has a half-life of 8 days. Dosing once a week, the next dose arrives 7 days later with about 55% of the previous one still on board. Levels therefore stack to roughly 2.2× a single dose before plateauing, which takes about 40 days — and after a final dose it takes about the same again to clear.
An oxyntomodulin-based design
Mazdutide is derived from oxyntomodulin, a naturally occurring peptide that activates both the GLP-1 and glucagon receptors on its own. That is a different starting point from engineering a single-receptor agonist and then adding a second activity — the dual action is native to the parent molecule rather than bolted on.
Its reported half-life is among the longest in this class and exceeds the weekly dosing interval comfortably. Both the time to reach a plateau and the time to clear after stopping run correspondingly long, which is worth understanding for anyone reasoning about intervals or breaks: the curve is slow at both ends.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.