Cagrilintide Half-Life Calculator
Cagrilintide is an investigational long-acting amylin analogue, studied both alone and alongside semaglutide. Its half-life is long enough that weekly dosing produces meaningful accumulation — this calculator charts what that looks like across the first several weeks.
Half-life 7.4 days · peaks at 2 days
Every 7 days.
Half-life
Left at next dose
Cagrilintide · once weekly · levels plateau after ~37 days
Steady-state peak
2.06 mg
Steady-state trough
1.27 mg
Accumulation
2.1×
At once weekly, each dose lands before the previous one has cleared, so levels stack to about 2.1× a single dose before plateauing — roughly 37 days in. After the last dose it takes about 37 days to clear.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published Cagrilintide half-life of about 7.4 days. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
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What a 7.4 days half-life means in practice
A half-life of 7.4 days against once a week dosing means each dose lands before the previous one has gone. That changes the curve in three ways:
1. One half-life
Half the dose is gone after 7.4 days. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once a week means the next dose lands 7 days later, with about 52% of the previous one still present.
3. Accumulation and plateau
Those leftovers stack until intake matches elimination — about 2.1× a single dose, reached after roughly 37 days (five half-lives).
Worked example
Cagrilintide has a half-life of 7.4 days. Dosing once a week, the next dose arrives 7 days later with about 52% of the previous one still on board. Levels therefore stack to roughly 2.1× a single dose before plateauing, which takes about 37 days — and after a final dose it takes about the same again to clear.
Amylin is a different pathway from GLP-1
Cagrilintide is not a GLP-1 receptor agonist. Amylin is a separate hormone, co-secreted with insulin, with its own receptors and its own effects on gastric emptying and satiety signalling. That is the rationale for studying it alongside a GLP-1 rather than as a competitor to one — two mechanisms rather than a stronger version of the same.
Its reported half-life is at the long end even among weekly compounds, exceeding the seven-day interval it is dosed on. When the half-life is longer than the interval, more than half of each dose survives to meet the next, and accumulation is correspondingly pronounced — the plateau sits well above a single dose and takes over a month to reach.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.