KPV Half-Life Calculator
KPV is a tripeptide corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone. At three amino acids it is about as small as a peptide gets, and its half-life is correspondingly short.
Half-life 30 min · peaks at 30 min
Every 24 hours.
Half-life
Left at next dose
KPV · once daily · levels plateau after ~2.5 hours
Steady-state peak
1 mg
Steady-state trough
0 mg
Accumulation
None
At once daily, each dose has essentially cleared before the next one — levels don't accumulate, they repeat the same rise and fall. Clearance after a dose takes about 2.5 hours.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published KPV half-life of about 30 min. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
Never do this math twice.
The Pep AI app remembers your vials and doses, shows an interactive syringe you draw to, counts down the doses left in each vial, and reminds you when it's time. Free on iOS and Android.
What a 30 min half-life means in practice
A half-life of 30 min against once daily dosing means each dose has essentially cleared before the next arrives. That shapes the curve in three ways:
1. One half-life
Half the dose is gone after 30 min. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once daily means the next dose lands 24 hours later, with about 0% of the previous one still present.
3. Accumulation and plateau
Almost nothing carries over, so levels don't accumulate — each dose repeats the same rise and fall, clearing in about 2.5 hours.
Worked example
KPV has a half-life of 30 min. Dosing once daily, the next dose arrives 24 hours later with about 0% of the previous one still on board. That's little enough that levels don't build up: each dose rises and falls on its own, clearing in about 2.5 hours.
Three amino acids from a larger hormone
KPV — lysine, proline, valine — is the final three residues of alpha-MSH. The interest in it rests on preclinical work suggesting the anti-inflammatory activity of the parent hormone survives in the fragment without the pigmentation effects that come with the full molecule.
That is a preclinical proposition rather than an established one. As with every fragment-of-a-larger-molecule compound, findings about the parent do not automatically transfer, and the fragment's own literature is considerably thinner. Its half-life is very short, so nothing accumulates at any realistic interval.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.