Ipamorelin Half-Life Calculator
Ipamorelin is a pentapeptide growth hormone secretagogue, notable in its class for selectivity. Its half-life is a couple of hours, so nothing accumulates between administrations — this calculator charts the shape.
Half-life 2 hours · peaks at 40 min
Every 24 hours.
Half-life
Left at next dose
Ipamorelin · once daily · levels plateau after ~10 hours
Steady-state peak
0.98 mg
Steady-state trough
0 mg
Accumulation
None
At once daily, each dose has essentially cleared before the next one — levels don't accumulate, they repeat the same rise and fall. Clearance after a dose takes about 10 hours.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published Ipamorelin half-life of about 2 hours. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
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What a 2 hours half-life means in practice
A half-life of 2 hours against once daily dosing means each dose has essentially cleared before the next arrives. That shapes the curve in three ways:
1. One half-life
Half the dose is gone after 2 hours. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once daily means the next dose lands 24 hours later, with about 0% of the previous one still present.
3. Accumulation and plateau
Almost nothing carries over, so levels don't accumulate — each dose repeats the same rise and fall, clearing in about 10 hours.
Worked example
Ipamorelin has a half-life of 2 hours. Dosing once daily, the next dose arrives 24 hours later with about 0% of the previous one still on board. That's little enough that levels don't build up: each dose rises and falls on its own, clearing in about 10 hours.
Selectivity is the distinguishing feature
Growth hormone secretagogues act at the ghrelin receptor to prompt release of growth hormone. The older members of the class also produced noticeable effects on cortisol, prolactin and appetite, because the receptor's signalling is not confined to one output. Ipamorelin's reputation rests on being comparatively selective — more of the intended effect, less of the rest.
Its half-life is short, and this matters more for secretagogues than for most compounds. Growth hormone is normally released in pulses, and continuous receptor stimulation would flatten that pattern rather than amplify it. A short-acting compound produces a pulse and then gets out of the way, which is closer to the physiological pattern than sustained presence would be.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.