Epithalon Half-Life Calculator
Epithalon is a synthetic tetrapeptide originating in Soviet-era research on pineal extracts. Its half-life is very short. The claims attached to it are unusually large relative to the evidence, which is worth knowing before reading anything about it.
Half-life 30 min · peaks at 45 min
Every 24 hours.
Half-life
Left at next dose
Epithalon · once daily · levels plateau after ~2.5 hours
Steady-state peak
1 mg
Steady-state trough
0 mg
Accumulation
None
At once daily, each dose has essentially cleared before the next one — levels don't accumulate, they repeat the same rise and fall. Clearance after a dose takes about 2.5 hours.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published Epithalon half-life of about 30 min. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
Never do this math twice.
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What a 30 min half-life means in practice
A half-life of 30 min against once daily dosing means each dose has essentially cleared before the next arrives. That shapes the curve in three ways:
1. One half-life
Half the dose is gone after 30 min. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once daily means the next dose lands 24 hours later, with about 0% of the previous one still present.
3. Accumulation and plateau
Almost nothing carries over, so levels don't accumulate — each dose repeats the same rise and fall, clearing in about 2.5 hours.
Worked example
Epithalon has a half-life of 30 min. Dosing once daily, the next dose arrives 24 hours later with about 0% of the previous one still on board. That's little enough that levels don't build up: each dose rises and falls on its own, clearing in about 2.5 hours.
A small peptide with an outsized claim set
Epithalon is four amino acids — alanine, glutamate, aspartate, glycine — developed as a synthetic version of a peptide fraction isolated from pineal tissue. Its research literature originates largely from a single institutional tradition and is substantially published in Russian-language journals, which limits how much of it has been independently replicated.
The claims commonly attached to it concern telomerase activity and lifespan, which are among the largest claims that can be made about any compound. The evidence base does not support them at the level they are usually stated, and the gap between the two is wider here than for almost anything else in this catalogue. Its half-life is very short and nothing accumulates.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.