ARA-290 Half-Life Calculator
ARA-290, also called cibinetide, is an eleven-amino-acid peptide derived from erythropoietin but engineered to separate tissue-protective signalling from EPO's blood-forming activity. Its half-life is very short — a matter of minutes.
Half-life 20 min · peaks at 30 min
Every 24 hours.
Half-life
Left at next dose
ARA-290 (Cibinetide) · once daily · levels plateau after ~1.7 hours
Steady-state peak
1 mg
Steady-state trough
0 mg
Accumulation
None
At once daily, each dose has essentially cleared before the next one — levels don't accumulate, they repeat the same rise and fall. Clearance after a dose takes about 1.7 hours.
This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.
Based on a published ARA-290 half-life of about 20 min. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.
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What a 20 min half-life means in practice
A half-life of 20 min against once daily dosing means each dose has essentially cleared before the next arrives. That shapes the curve in three ways:
1. One half-life
Half the dose is gone after 20 min. After two half-lives 25% remains, after three 12.5%.
2. What's left at the next dose
Dosing once daily means the next dose lands 24 hours later, with about 0% of the previous one still present.
3. Accumulation and plateau
Almost nothing carries over, so levels don't accumulate — each dose repeats the same rise and fall, clearing in about 1.7 hours.
Worked example
ARA-290 (Cibinetide) has a half-life of 20 min. Dosing once daily, the next dose arrives 24 hours later with about 0% of the previous one still on board. That's little enough that levels don't build up: each dose rises and falls on its own, clearing in about 1.7 hours.
EPO-derived, without the erythropoiesis
Erythropoietin has two distinct activities: stimulating red blood cell production, and a tissue-protective signalling role through a separate receptor complex. ARA-290 was designed to capture the second without the first, which is the entire point of the molecule — the haematological effects that make EPO both useful and dangerous are absent.
It has been investigated clinically in specific indications, notably neuropathic conditions, which puts it further along than most compounds in this catalogue. Its half-life is extremely short, measured in minutes, so the curve is a sharp spike and complete clearance with no accumulation whatsoever.
Frequently asked questions
This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.
Built by the Pep AI team.