5-Amino-1MQ Half-Life Calculator

    5-Amino-1MQ is not a peptide. It is a small molecule inhibitor of the enzyme NNMT, sold and discussed alongside peptides but chemically unrelated to them — which changes how it is absorbed and cleared.

    Half-life 6.9 hours · peaks at 1 hour

    Every 24 hours.

    Half-life

    6.9 hours

    Left at next dose

    9%

    5-Amino-1MQ · once daily · levels plateau after ~35 hours

    00.510d1d2d3d4dmg

    Steady-state peak

    1.1 mg

    Steady-state trough

    0.11 mg

    Accumulation

    1.1×

    At once daily, each dose lands before the previous one has cleared, so levels stack to about 1.1× a single dose before plateauing — roughly 35 hours in. After the last dose it takes about 35 hours to clear.

    This is a modelled estimate of relative levels from published half-life and time-to-peak figures — not a measured blood concentration. Individual pharmacokinetics vary.

    Based on a published 5-Amino-1MQ half-life of about 6.9 hours. The chart models RELATIVE levels from a unit dose — enter your own figures to see the shape. It is not a dose recommendation.

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    What a 6.9 hours half-life means in practice

    A half-life of 6.9 hours against once daily dosing means each dose lands before the previous one has gone. That changes the curve in three ways:

    1. 1. One half-life

      Half the dose is gone after 6.9 hours. After two half-lives 25% remains, after three 12.5%.

    2. 2. What's left at the next dose

      Dosing once daily means the next dose lands 24 hours later, with about 9% of the previous one still present.

    3. 3. Accumulation and plateau

      Those leftovers stack until intake matches elimination — about 1.1× a single dose, reached after roughly 35 hours (five half-lives).

    Worked example

    5-Amino-1MQ has a half-life of 6.9 hours. Dosing once daily, the next dose arrives 24 hours later with about 9% of the previous one still on board. Levels therefore stack to roughly 1.1× a single dose before plateauing, which takes about 35 hours — and after a final dose it takes about the same again to clear.

    A small molecule in a peptide catalogue

    5-Amino-1MQ is a quinolinium compound that inhibits nicotinamide N-methyltransferase. It contains no amino acids and no peptide bonds, and it ends up in peptide catalogues because of where it is sold rather than what it is.

    The practical difference is real. Peptides are destroyed by digestion, which is why they are injected; small molecules of this kind are often orally available. Their clearance also proceeds through different routes — hepatic metabolism rather than peptidase cleavage and renal filtration — which is why its half-life is longer than most peptides in the same catalogue despite being a smaller molecule.

    Frequently asked questions

    This calculator is provided for informational and educational purposes only and is not medical advice. Always confirm dosing with a qualified healthcare professional and double-check your own measurements before administering anything.

    Built by the Pep AI team.